C. W. Parker, M.D.; J. A. Thiel, M.D.
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Based on immunologic principles established in the experimental animal, human penicillin hypersensitivity must be presumed to be due to groups formed by the degradation of penicillin and capable of covalent binding to protein. Three such groups are the penicilloyl, penicillenate, and penamaldate derivatives. Based on wheal-and-erythema responses using derivatives containing these groups in the skin of persons with penicillin allergy, hypersensitivity to the penicilloyl group has been found to be very common in penicillin hypersensitivity. Allergy to penicillenate and penamaldate groups appears to be considerably less common.
In large-scale testing of human subjects, a polymer of lysine has been used
Parker CW, Thiel JA. Skin Testing in Penicillin Allergy.. Ann Intern Med. ;58:738. doi: 10.7326/0003-4819-58-4-738_1
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Published: Ann Intern Med. 1963;58(4):738.
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