J. R. Gill Jr., M.D. (Associate); F. C. Bartter, M.D.; P. Pronove, M.D.; R. C. MacCardle, Ph.D.
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Hyperplasia and hypertrophy of the juxtaglomerular apparatus, and increased aldosterone production which hypokalemic alkalosis, have been found to be associated with normal blood pressure in 2 Negro boys, C. T. and M. W., ages 10 and 25 years, respectively. Growth and development were retarded in both patients, most markedly in C. J., who showed proportional dwarfism. Hypokalemia was known to be present at 5 years in C. J. and at 16 years in M. W. Serum potassium (K) and carbon dioxide (CO2) ranged from 1.3 to 2.2 mEq/liter and 29 to 37 mEq/liter, respectively; serum Na was also depressed. Urinary
Gill JR, Bartter FC, Pronove P, et al. Hyperplasia of the Juxtaglomerular Complex with Hyperaldosteronism and Hypokalemic Alkalosis.. Ann Intern Med. 1963;58:740. doi: https://doi.org/10.7326/0003-4819-58-4-740_1
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Published: Ann Intern Med. 1963;58(4):740.
Adrenal Disorders, Endocrine and Metabolism.
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