S. Papper, M.D., F.A.C.P.
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There has been considerable debate concerning the existence of renal failure occurring in the course of Laennec's cirrhosis in the absence of causes of renal insufficiency.
Our group has studied 46 patients with cirrhosis who developed renal failure without apparent cause.
The group was not a homogeneous one clinically. Jaundice and ascites ranged from minimal to severe. Histologically, the liver revealed various stages of cirrhosis.
The following evidence suggests that renal failure was due to a disturbance of renal circulation, rather than to any parenchymal lesion: (1) renal failure developed abruptly; (2) blood pressure was generally reduced; (3) renal blood
Papper S. Renal Failure in Laennec's Cirrhosis ("Hepatorenal Syndrome").. Ann Intern Med. 1963;58:742. doi: https://doi.org/10.7326/0003-4819-58-4-742_2
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Published: Ann Intern Med. 1963;58(4):742.
Gastroenterology/Hepatology, Liver Disease, Nephrology.
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