W. C. Thomas Jr., M.D., F.A.C.P.
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Cartilage matrix obtained from rachitic animals will mineralize in vitro if placed in an inorganic solution containing small amounts of calcium (6 mg/100 ml) and phosphorus (5 mg/100 ml). It has been demonstrated recently that urine from calculous patients also readily mineralizes such cartilage matrix, whereas that from most normal subjects does not, even though the urines have similar calcium and phosphorus content. These observations are thought to be pertinent to the problem of renal stone formation, and delineation of factors accounting for the different mineralizing propensities of the 2 types of urines are in progress. Certain trace elements, pyrophosphates
Thomas WC. Urinary Constituents Affecting Mineralization.. Ann Intern Med. 1963;58:743–744. doi: https://doi.org/10.7326/0003-4819-58-4-743_3
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Published: Ann Intern Med. 1963;58(4):743-744.
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