ALAN SOLOMON, M.D.; JOHN L. FAHEY, M.D.
Death or disability of a patient with malignant disease may result from direct growth of the tumor or from the elaboration of some harmful product. In the latter instance it should be possible to alter the disease course by modification or removal of the offending substance. At the present time, however, there are a few situations where a deleterious substance present in an excessive amount can be removed in a practicable way. In polycythemia vera, reduction of red blood cell mass by removal of whole blood is a standard form of therapy (1). In primary (Waldenström's) macroglobulinemia, removal of the
SOLOMON A, FAHEY JL. Plasmapheresis Therapy in Macroglobulinemia. Ann Intern Med. ;58:789–800. doi: 10.7326/0003-4819-58-5-789
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Published: Ann Intern Med. 1963;58(5):789-800.
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