CHARLES E. MENGEL, M.D.
Cutaneous phenomena are the most characteristic and frequently recognized of the various clinical manifestations of the carcinoid syndrome. These occur as spontaneous or induced intermittent phenomena, a variety of colors being described (1-7). In addition, permanent changes with dilatation of capillaries and venules of the skin with a telangiectatic and permanent cyanotic appearance occur late in the course of the disease. These changes may be related in some way to increased circulating serotonin, histamine, or both. The occasional occurrence of pellagrinous cutaneous manifestations in these patients seems to be related to the development of niacin deficiency, secondary to both chronic
MENGEL CE. Cutaneous Manifestations of the Malignant Carcinoid Syndrome: Severe Pruritus and Orange Blotches. Ann Intern Med. 1963;58:989–993. doi: https://doi.org/10.7326/0003-4819-58-6-989
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Published: Ann Intern Med. 1963;58(6):989-993.
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