EMIL J. FREIREICH, M.D.; ALLAN KLIMAN, M.D.; LAWRENCE A. GAYDOS, M.D.; NATHAN MANTEL, M.A.; EMIL FREI III, M.D.
More than a half century has passed since Duke (2) demonstrated that transfusion of platelets to thrombocytopenic patients could raise the circulating platelet count and arrest hemorrhage. These observations have been repeatedly confirmed in man and experimental animals (3-6). Nevertheless, platelet transfusion therapy is not widely practiced but is reserved for short-term treatment of thrombopenia associated with serious hemorrhage or for preoperative use (3-5, 7). A major reason for this is an inadequate supply of platelets for transfusion. The short platelet life-span of 5 to 8 days necessitates frequent transfusions, and because no effective storage technique is known, only freshly
FREIREICH EJ, KLIMAN A, GAYDOS LA, et al. Response to Repeated Platelet Transfusion from the Same Donor. Ann Intern Med. 1963;59:277–287. doi: 10.7326/0003-4819-59-3-277
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Published: Ann Intern Med. 1963;59(3):277-287.
Infectious Disease, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
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