JOHN J. SCHMIDT, M.D.; HAROLD J. ROBINSON, M.D.; CHARLES S. PENNYPACKER, M.D., F.A.C.P.
The appearance of plasma cells in the peripheral blood in appreciable numbers is an uncommon event. More seriously, this occurrence is a sign of proliferative disease of the plasma cell system. Peripheral plasmacytosis may also occur in certain viral diseases (1-4). A third situation so characterized is serum sickness (5). With the widespread use of active immunization and the introduction of antibiotics, the incidence of true serum sickness has waned. Therefore, it is deemed important to report a case of severe, explosive, accelerated serum sickness that was accompanied by a reactive peripheral plasmacytosis. Coincident with this, there was a demonstration
SCHMIDT JJ, ROBINSON HJ, PENNYPACKER CS. Peripheral Plasmacytosis in Serum Sickness. Ann Intern Med. ;59:542–546. doi: 10.7326/0003-4819-59-4-542
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Published: Ann Intern Med. 1963;59(4):542-546.
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