PAUL P. CARBONE, M.D.; J. H. TJIO, M.D.; JACQUELINE WHANG, M.D.; JEROME B. BLOCK, M.D.; WILLIAM B. KREMER, M.D.; EMIL FREI III, M.D.
Chemotherapy or X irradiation produces improvement in the clinical and hematologic abnormalities in the majority of patients with chronic myelogenous leukemia (CML) (1-5). Return of the leukocyte alkaline phosphatase (LAP) and bone marrow morphology toward normal has been described but is less frequent (6-11). Recently, Tough and co-workers (12) have reported that the chromosome abnormality (Ph1) which is present in the majority of patients with CML disappears from the peripheral blood but not from the marrow after splenic X irradiation. The present study was designed to determine the relative frequency and magnitude of response of clinical, hematologic, and cytogenetic abnormalities
CARBONE PP, TJIO JH, WHANG J, et al. The Effect of Treatment in Patients with Chronic Myelogenous Leukemia: Hematologic and Cytogenetic Studies. Ann Intern Med. 1963;59:622–628. doi: https://doi.org/10.7326/0003-4819-59-5-622
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Published: Ann Intern Med. 1963;59(5_Part_1):622-628.
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