GEORGE R. THOMPSON, M.D.; WILLIAM MARTEL, M.D.; MILOVAN T. RAKIC, M.D.; JOHN T. HAYES, M.D.
That genetic factors exist in ankylosing spondylitis is generally accepted. Several reports (1, 2) have suggested that this disease is inherited as if due to an autosomal dominant gene with variable penetrance, being manifest much more frequently in the male. While this seems to be true in some instances, in others it would appear that the heredity is more complex and is the result of several genetic factors (3, 4).
It has also been suggested that hyperuricemia and gout are inherited as autosomal dominant characteristics with variable penetrance (5-7), with clinical manifestations occurring more frequently in males than in females.
THOMPSON GR, MARTEL W, RAKIC MT, et al. Ankylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral Junction: A Family Study. Ann Intern Med. 1963;59:848–858. doi: https://doi.org/10.7326/0003-4819-59-6-848
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Published: Ann Intern Med. 1963;59(6):848-858.
Infectious Disease, Rheumatology.
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