DAVID S. NEWCOMBE, M.D.; ALAN S. COHEN, M.D.
Since the introduction of relatively simple and specific methods for the analysis of human chromosomes, studies of heritable or genetically determined disorders have been extensive. Rheumatoid spondylitis would appear to be an appropriate disorder for such chromosome analyses for several reasons. First, there are indications that genetic mechanisms may play a role in its etiology, that is, the strong tendency toward the familial occurrence of spondylitis, the apparently autosomal dominant type of inheritance with incomplete penetrance, and the appearance of the disorder in twins (1). Second, X-irradiation, now associated with a documented increased incidence of leukemia (2), has been used
NEWCOMBE DS, COHEN AS. Chromosome Patterns in Irradiated and Nonirradiated Patients with Rheumatoid Spondylitis. Ann Intern Med. ;59:859–864. doi: 10.7326/0003-4819-59-6-859
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Published: Ann Intern Med. 1963;59(6):859-864.
Infectious Disease, Rheumatology.
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