NATHANIEL I. BERLIN, M.D.; DAVID RALL, M.D.; J. A. R. MEAD, PH.D.; EMIL J FREIREICH, M.D.; EUGENE VAN SCOTT, M.D.; ROY HERTZ, M.D.; MORTIMER B. LIPSETT, M.D.
Dr. Nathaniel I. Berlin: Since the introduction in 1947, of the folic acid antagonists for treatment of neoplastic diseases, there have been a number of studies designed to determine the mechanism of their action and their role in cancer chemotherapy. The papers selected for presentation at this conference were designed to summarize the present knowledge of the folic acid antagonists. To this end, the pharmacology and biochemistry are being presented together with reports of therapeutic usefulness in acute leukemia, diseases of the skin, and choriocarcinoma. While excellent therapeutic effects can be achieved, it is with some cost in toxicity. For
BERLIN NI, RALL D, MEAD JAR, et al. Folic Acid Antagonists: Effects on the Cell and the Patient Combined Clinical Staff Conference at the National Institutes of Health. Ann Intern Med. 1963;59:931–957. doi: 10.7326/0003-4819-59-6-931
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Published: Ann Intern Med. 1963;59(6):931-957.
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