NUZHET O. ATUK, M.D.; ALFON MOSCA, M.D.; CALVIN KUNIN, M.D.
One of the most troublesome complications of severe renal disease is infection (1, 2). Bacterial invasion of wounds, cut down sites, the lungs, and urinary tract appear to be poorly controlled by the uremic patient; infection may become disseminated and is frequently the cause of death. Gram-negative infections of the urinary tract are of particular concern since they may lead to further embarassment of already compromised renal function; in addition, bacterial endotoxin released from these organisms is capable of producing profound renal damage (3).
Accordingly, many workers in this field have urged particular care toward the prevention of such infections
ATUK NO, MOSCA A, KUNIN C. The Use of Potentially Nephrotoxic Antibiotics in the Treatment of Gram-negative Infections in Uremic Patients. Ann Intern Med. ;60:28–38. doi: 10.7326/0003-4819-60-1-28
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Published: Ann Intern Med. 1964;60(1):28-38.
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