MICHAEL A. GOLDSTEIN, M.D.; NONGNUCH PATPONGPANIJ, M.D.; VIRGINIA MINNICH, M.S.
Hemoglobin A2 is present in a concentration of less than 3.3 per cent of the total hemoglobin in all normal adults (1). Elevation above this level is known to accompany the erythrocyte abnormalities seen in classical thalassemia trait (1, 2). Whereas thalassemia major has rarely been described in the American Negro, many cases of sickle cell thalassemia have been reported in this race (summarized by Dacie (3)). It seemed of interest, therefore, to screen a random population of Negroes for an exact estimate of the prevalence of elevated hemoglobin A2 values. The results obtained revealed an increased amount of hemoglobin
GOLDSTEIN MA, PATPONGPANIJ N, MINNICH V. The Incidence of Elevated Hemoglobin A2 Levels in the American Negro. Ann Intern Med. 1964;60:95–99. doi: 10.7326/0003-4819-60-1-95
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Published: Ann Intern Med. 1964;60(1):95-99.
Hematology/Oncology, Red Cell Disorders.
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