JAMES D. TOWNSEND, M.D.
The diagnosis of acute intermittent porphyria (AIP) is ordinarily made by demonstrating the presence of porphobilinogen (PBG) in freshly passed urine. In 1941 Watson and Scwartz (1) described a simple test for the detection of this substance in the urine. In 1948 Hammond and Welker (2) reported that they were unable to find a single false positive in a thousand urine samples from routine hospital admissions. Because of this the test has been regarded as highly reliable, and the finding of a positive result is looked upon as almost pathognomonic of the disease. However, interpretation of the test may occasionally
TOWNSEND JD. An Evaluation of a Recent Modification of the Watson-Schwartz Test for Porphobilinogen. Ann Intern Med. ;60:306–307. doi: 10.7326/0003-4819-60-2-306
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Published: Ann Intern Med. 1964;60(2_Part_1):306-307.
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