George R. Thompson, M.D.; Milovan T. Rakic, M.D.; William Martel, M.D.; John T. Hayes, M.D.
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It is generally accepted that genetic factors are important in ankylosing spondylitis, hyperuricemia, and gout. While it is probably not a unique association, to our knowledge, there are no reports of these illnesses occurring in the same patient. It therefore seems pertinent to call attention to a family in which hyperuricemia and gout, ankylosing spondylitis, and various developmental anomalies of the lower spine occurred in several members of three generations.
The propositus, a 44-year-old man, had tophaceous gout, ankylosing spondylitis, and a transitional lumbosacral vertebra with spine bifida. Of his eight children, two had ankylosing spondylitis, one of whom also
Thompson GR, Rakic MT, Martel W, et al. Ankylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral Junction: A Family Study.. Ann Intern Med. 1964;60:315. doi: https://doi.org/10.7326/0003-4819-60-2-315_1
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Published: Ann Intern Med. 1964;60(2_Part_1):315.
Infectious Disease, Rheumatology.
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