William R. Wilson, M.D., F.A.C.P.; Daniel B. Stone, M.D.; Ronald Okun, M.D.; R. Patterson Russell, M.D.
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A double-blind study of the metabolic effects of trichlormethiazide (TCZ) and diazoxide was performed in 45 hypertensive patients. Each patient received TCZ, 8 mg/day for 3 weeks, then was randomly allocated to one of three groups for 4 weeks. Fifteen patients received TCZ, 8 mg/day (group I); 15 patients received TCZ, 8 mg plus diazoxide, 200 mg, daily (group II); 15 patients received TCZ, 8 mg plus diazoxide, 400 mg, daily (group III). Two-hour postprandial blood sugars (PPBS), serum urea nitrogen (SUN) and serum uric acid (SUA) were measured before and after the trial.
"Thiazide hyperglycemia" developed in 17 patients;
Wilson WR, Stone DB, Okun R, et al. Metabolic Effects of Diuretic and Nondiuretic Benzothiadiazines.. Ann Intern Med. 1964;60:317. doi: 10.7326/0003-4819-60-2-317_1
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Published: Ann Intern Med. 1964;60(2_Part_1):317.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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