ALVAN R. FEINSTEIN, M.D.; HARRISON F. WOOD, M.D.; MARIO SPAGNUOLO, M.D.; ANGELO TARANTA, M.D.; SARAN JONAS, M.D.; EDITH KLEINBERG, B.S.; ESTHER TURSKY, R.N.
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What are the cardiac sequelae of acute rheumatic fever? How often does insidious valvular scarring bring rheumatic cardiac damage to patients who initially seemed free of it? How well can we identify the patients who will do poorly or those who will remain permanently free of rheumatic heart disease? Is death at a young age invariably due to persistent or recurrent "rheumatic activity"?
Although these and other clinical questions about rheumatic fever have often been asked and answered in the past, the existing answers have come from studies whose methods could not provide entirely satisfactory explorations of the issues involved.
FEINSTEIN AR, WOOD HF, SPAGNUOLO M, et al. Rheumatic Fever in Children and Adolescents: A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae: VII. Cardiac Changes and Sequelae. Ann Intern Med. 1964;60:87–123. doi: 10.7326/0003-4819-60-2-87
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Published: Ann Intern Med. 1964;60(2_Part_2):87-123.
DOI: 10.7326/0003-4819-60-2-87
Cardiology, Infectious Disease, Rheumatology, Streptococcal Infections.
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