M. LERTZMAN, M.D.; B. M. FROME, M.D.; L. G. ISRAELS, M.D.; R. M. CHERNIACK, M.D., F.A.C.P.
It is generally considered that the demonstration of arterial oxygen unsaturation in a patient with polycythemia indicates a secondary rather than a primary cause for the increase in red cell mass (1-3). While hypoxia has been demonstrated in some patients with polycythemia vera (4-6) it has been attributed in these instances to co-existent cardiorespiratory disease (1, 6) or aging (7).
The present study demonstrates that the arterial oxygen tension may be low in patients with polycythemia vera who have no demonstrable co-existent cardiorespiratory disease and presents evidence that the hypoxia may be the result of an abnormality of the pulmonary
LERTZMAN M, FROME BM, ISRAELS LG, et al. Hypoxia in Polycythemia Vera. Ann Intern Med. 1964;60:409–417. doi: 10.7326/0003-4819-60-3-409
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Published: Ann Intern Med. 1964;60(3):409-417.
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