Timothy J. Regan, M.D.; Christos B. Moschos, M.D.; Pablo Casanegra, M.D.; Gabriel Koroxenidis, M.D.; Harper K. Hellems, M.D., F.A.C.P.
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In view of the ill-defined status of cardiac involvement in chronic alcoholism, a study of the acute effects of ethanol on myocardial metabolism and function has been undertaken in animals considered nutritionally normal. The transport of various substrates by the left ventricle was studied for a 5-hr period in ten intact dogs. Fifteen per cent ethanol was infused for 2 hr at a rate of 0.1 ml/kg/min. Simultaneous arterial-coronary sinus sampling was performed at 15-min intervals. Observations were made of enzyme and ion leakage from heart muscle for evidence of necrosis, and the maximum rate of left-ventricular pressure rise was
Regan TJ, Moschos CB, Casanegra P, et al. Depression of Cardiac Function and Altered Myocardial Metabolism After Ethanol.. Ann Intern Med. 1964;60:709–710. doi: https://doi.org/10.7326/0003-4819-60-4-709_3
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Published: Ann Intern Med. 1964;60(4):709-710.
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