James E. Doherty, M.D., F.A.C.P.; W. H. Perkins, M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
Patients with hypothyroidism appear to be sensitive to digoxin while patients with hyperthyroidism appear to be somewhat resistant to the effects of the drug. This study was undertaken to compare blood levels and excretion of digoxin of patients with thyroid disease to patients with normal thyroid function.
Eleven patients with hyperthyroidism and 7 patients with hypothyroidism, as determined by clinical symptoms, I131 uptake, and PBI, were given 1.0 mg of tritiated digoxin intravenously to detect any difference in serum concentrations and excretion when compared to a group of 13 euthyroid patients with congestive heart failure.
Frequent serum specimens, urine, and
Doherty JE, Perkins WH. Tritiated Digoxin Studies in Thyroid Disease.. Ann Intern Med. ;60:715. doi: 10.7326/0003-4819-60-4-715_1
Download citation file:
Published: Ann Intern Med. 1964;60(4):715.
Endocrine and Metabolism, Thyroid Disorders.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use