STANLEY C. LEONBERG JR., M.D.; JOSEPH B. GREEN, M.D.; FRANK A. ELLIOTT, M.D.
The parenteral administration of reserpine is advocated by many authorities for the treatment of acute hypertensive crises. According to Moyer and Brest (1), parenterally administered reserpine "combines potency, ease of administration and safety." In their experience, excessive hypotension is relatively rare with such therapy, and they indicate that vasopressor agents are usually effective in correcting complications. Hoobler and Blaquier (2) recommend reserpine, finding it especially effective in moderating hypertensive crises, and add that acute shock does not result from an over-dosage with this drug.
The recommended dosages of reserpine for this purpose range, generally, from 1.0 to 5.0 mg intramuscularly or
LEONBERG SC, GREEN JB, ELLIOTT FA. The Response of Stroke Patients to Very Small Doses of Parenteral Reserpine. Ann Intern Med. ;60:866–870. doi: 10.7326/0003-4819-60-5-866
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Published: Ann Intern Med. 1964;60(5):866-870.
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