LAWRENCE D. WRUBLE, M.D.; G. WILLIAM COLE, M.D.; HOWARD E. LESSNER, M.D., F.A.C.P. (ASSOCIATE); S. Z. HENRICK HAIDRI, PH.D.; MARTIN H. KALSER, M.D., PH.D., F.A.C.P.
The site of production of human gastric intrinsic factor has not been conclusively demonstrated. Previous studies have been done with either in vitro (1, 2) or postmortem speciments of human stomachs (3). Although these studies have indicated that most intrinsic factor activity is present in the fundus, with little or none in the antrum, no in vivo confirmatory studies have as yet been reported. A patient with the Zollinger-Ellison syndrome for which a parietal cell mass resection, leaving only the antrum, was to be performed, afforded us an opportunity to delineate in vivo the site of origin of human intrinsic
WRUBLE LD, COLE GW, LESSNER HE, et al. Evidence for the Fundic Origin of Intrinsic Factor: An in Vivo Study. Ann Intern Med. 1964;60:877–881. doi: 10.7326/0003-4819-60-5-877
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Published: Ann Intern Med. 1964;60(5):877-881.
Gastroenterology/Hepatology, Hematology/Oncology, Lupus Erythematosus, Red Cell Disorders, Rheumatology.
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