ADAM S. LITTLE, M.D., F.R.C.P.; HAROLD E. BELL, M.D.
In 1961, Levin and Pinkus (1) reported the case of a 40-year-old Negro woman who for 4 years had suffered from acute and painful ecchymoses confined to her extremities. The lesions were preceded by a wheal which soon became hemorrhagic. The longest asymptomatic period in the 4 years had been 4 days. The intradermal injection of a solution of the patient's lysed leukocytes and a solution of deoxyribonucleic acid (DNA) obtained from calf thymus gland each produced hemorrhages in the skin of the extremities but failed to do so in the skin of the trunk. Similar injections using ribonucleic acid
LITTLE AS, BELL HE. Painful Subcutaneous Hemorrhages of the Extremities with Unusual Reaction to Injected Deoxyribonucleic Acid. Ann Intern Med. 1964;60:886–891. doi: https://doi.org/10.7326/0003-4819-60-5-886
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Published: Ann Intern Med. 1964;60(5):886-891.
Emergency Medicine, Hospital Medicine.
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