JAY P. SANFORD, M.D.
Advances in antimicrobial therapy have been accompanied by an increased frequency of infections due to micro-organisms which are resistant to commonly utilized antibiotics. Although such resistant infections occur most frequently in hospital practice, they are also subsequently encountered in the community at large.
This group of infections commonly has two major features which determine their occurrence and are important in their control:  They occur within an environment in which antibiotic-resistant bacteria are prevalent. Widespread use of antibacterial agents alters the normal bacterial flora of patients, medical personnel, and nonsterile equipment in favor of resistant
SANFORD JP. Hospital-acquired Urinary-Tract Infections. Ann Intern Med. 1964;60:903–914. doi: https://doi.org/10.7326/0003-4819-60-5-903
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Published: Ann Intern Med. 1964;60(5):903-914.
Hospital Medicine, Infectious Disease.
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