W. S. REVENO, M.D., F.A.C.P.; H. ROSENBAUM, M.D., F.A.C.P.
In this report we have summarized twenty years' experience in the treatment of hyperthyroidism with antithyroid drugs. While the primary aim was to determine the long-term effectiveness of this form of therapy, the study provided the opportunity to observe the response in postoperative or recurrent hyperthyroidism, when pregnancy or diabetes complicated the thyrotoxicosis, and in iatrogenic disease. Also described are the unfavorable reactions to the drugs and several instances of unresponsiveness to treatment because of false hyperthyroidism.
Thiouracil, the first drug used, has been replaced by propylthiouracil and methimazole, both drugs of high efficacy and low toxicity. Potassium perchlorate, the
REVENO WS, ROSENBAUM H. Observations on the Use of Antithyroid Drugs. Ann Intern Med. ;60:982–989. doi: 10.7326/0003-4819-60-6-982
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Published: Ann Intern Med. 1964;60(6):982-989.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hospital Medicine.
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