FRANCIS N. LOHRENZ, M.D.; RAFAEL FERNANDEZ, M.D.; RICHARD P. DOE, M.D.
Case reports of patients with isolated deficiency of one of the tropic hormones of the pituitary gland are now well-documented, although panhypopituitarism is still by far the more common disorder (1-4). Of these isolated deficiencies, inadequate gonadotropin secretion is the most common. Tumors, idiopathic atrophy, or infarctions of the pituitary gland in adults may present with the features of hypogonadotropic hypogonadism and develop thyrotropin-stimulating hormone (TSH) and adrenocorticotropic hormone (ACTH) deficiency later in their course (1, 5, 6). Prepubertal hypogonadtropic hypogonadism also may be due to a space occupying lesion, infarction, idiopathic atrophy, or be a phase of severe debilitating
LOHRENZ FN, FERNANDEZ R, DOE RP. Isolated Thyrotropin Deficiency: Review and Report of Three Cases. Ann Intern Med. 1964;60:990–998. doi: 10.7326/0003-4819-60-6-990
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Published: Ann Intern Med. 1964;60(6):990-998.
Endocrine and Metabolism, Thyroid Disorders.
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