PETER I. REED, M.D., M.R.C.P.; CHARLES B. CLAYMAN, M.D., F.A.C.P.; WALTER L. PALMER, M.D., PH.D., M.A.C.P.
The purpose of this study was to investigate the effect of prolonged administration of corticotropin in high dosage on the function of the adrenal cortex and the pituitary gland. More information is available on the action of the adrenal steroids (1-9), than on that of adrenocorticotrophic hormone (ACTH) (10-12).
Thirteen patients with chronic ulcerative colitis or regional enteritis had been receiving ACTH for months and years, in two instances, over 8 and 9 years, respectively.
1. The daily morning administration of ACTH (usually between 8:30 and 10:00 AM) was continued throughout the test period. Adrenal reserve was
REED PI, CLAYMAN CB, PALMER WL. Adrenocortical and Pituitary Responsiveness Following Long-term, High Dosage Corticotropin Administration. Ann Intern Med. ;61:1–10. doi: 10.7326/0003-4819-61-1-1
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Published: Ann Intern Med. 1964;61(1):1-10.
Endocrine and Metabolism, Neurology, Pituitary Disorders.
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