T. S. DANOWSKI, M.D.; JAMES V. BONESSI, M.D.; GEORGE SABEH, M.D.; ROGER D. SUTTON, M.D.; MARSHALL W. WEBSTER JR.; MARGARET E. SARVER, M.D.
Data accumulated in this laboratory provide a basis for some generalizations concerning pituitary-adrenal responsiveness in subjects who had received adrenal steroids or adrenocorticotrophic hormone (ACTH) in small or large dosages for brief or for prolonged periods and in spontaneous Cushing's syndrome in remission after removal of an adrenal adenoma.
Group A was made up of 117 females, 9.5 to 52 years of age, who received hydrocortisone-type steroids in replacement-displacement (that is, small) dosages in treatment of amenorrhea, hirsutism, acne, or infertility, and combinations thereof (Table 1). In most of these, the pretherapy urinary 17-ketosteroids (1)
DANOWSKI TS, BONESSI JV, SABEH G, SUTTON RD, WEBSTER MW, SARVER ME. Probabilities of Pituitary-Adrenal Responsiveness After Steroid Therapy. Ann Intern Med. ;61:11–26. doi: 10.7326/0003-4819-61-1-11
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Published: Ann Intern Med. 1964;61(1):11-26.
Adrenal Disorders, Endocrine and Metabolism, Neurology, Pituitary Disorders.
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