RUSSELL E. RANDALL JR., M.D.; M. DAVID COHEN, M.D.; CHARLES C. SPRAY JR., M.D.; ELSIE C. ROSSMEISL, M.A.
Magnesium is the fourth most abundant cation in the body. In a 70-kg man there are approximately 1,000 mEq of magnesium in bone, another 1,000 mEq within cells, and 20 mEq in plasma and interstitial fluid. In normal persons all the magnesium absorbed from the intestinal tract is excreted by the kidneys, as is parenterally administered magnesium (1-5). If the dietary intake of magnesium is curtailed, renal conservation of magnesium occurs (3, 6), and if magnesium depletion results from extra-renal losses, magnesium virtually disappears from the urine (3-5, 7).
In renal disease the ability to excrete magnesium may be severely
RANDALL RE, COHEN MD, SPRAY CC, et al. Hypermagnesemia in Renal Failure: Etiology and Toxic Manifestations. Ann Intern Med. 1964;61:73–88. doi: 10.7326/0003-4819-61-1-73
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Published: Ann Intern Med. 1964;61(1):73-88.
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