WILLIAM T. BUTLER, M.D.; JOHN E. BENNETT, M.D.; DAVID W. ALLING, M.D., PH.D.; PAUL T. WERTLAKE, M.D.; JOHN P. UTZ, M.D.; GEORGE J. HILL II, M.D.
Amphotericin B is the only available drug effective in preventing death from a number of systemic fungal infections. As a result, the drug is widely used despite toxic properties that in other circumstances would render it unacceptable. Important among these toxic effects are impairment of renal function and damage to renal structure.
It has been reported that azotemia, decreased renal concentrating power, and decreased phenolsulfonphthalein excretion occur in about three fourths of the patients during the course of administration of amphotericin B (1-7). The significance of the nephrotoxicity of amphotericin B is emphasized by the fact that the daily dose
BUTLER WT, BENNETT JE, ALLING DW, WERTLAKE PT, UTZ JP, HILL GJ. Nephrotoxicity of Amphotericin B: Early and Late Effects in 81 Patients. Ann Intern Med. ;61:175–187. doi: 10.7326/0003-4819-61-2-175
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Published: Ann Intern Med. 1964;61(2):175-187.
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