JULIO E. FIGUEROA, M.D.; SATORU NAKAMOTO, M.D.; EUGENE F. POUTASSE, M.D.; WILLEM J. KOLFF, M.D.
Thousands of persons die every year throughout the world because of chronic renal disease. The treatment of these patients, once the uremic stage is reached, has consisted mainly of palliation, dietary and fluid restriction, and electrolyte therapy, in an effort to restore the metabolic balance.
The first major step towards more effective treatment of chronic uremia was accomplished in 1941, when the artificial kidney was introduced by Kolff (1). This technique, commonly used in the treatment of acute renal failure, now permits the maintenance of life in patients with virtually no renal function for prolonged periods of time (2, 3).
FIGUEROA JE, NAKAMOTO S, POUTASSE EF, KOLFF WJ. Renal Homotransplantation in Man: Report of Six Consecutive Cases. Ann Intern Med. 1964;61:188–207. doi: 10.7326/0003-4819-61-2-188
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Published: Ann Intern Med. 1964;61(2):188-207.
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