ANANDA S. PRASAD, M.D., PH.D.; M. A. ABOUD, M.R.C.P., D.C.H.; A. SALAWI, M.D.; ARTHUR R. SCHULERT, PH.D.
Bruton first described primary agammaglobulinemia in male children in 1952 (1). Soon after, this condition was reported in adult females (2-5). This led to the recognition of two types of primary agammaglobulinemia: the congenital type seen in male children and an acquired variety occurring in adults of both sexes. Since then, approximately 200 cases of both kinds have been reported (6). Subsequently it has been shown that these patients have small quantities of gamma globulin in their plasma, and therefore the condition properly should be designated as hypogammaglobulinemia (7, 8). According to Good, Zak, Condie, and Bridges (8), the clinical
PRASAD AS, ABOUD MA, SALAWI A, SCHULERT AR. Hypogammaglobulinemia: Iodinated Gamma Globulin Studies. Ann Intern Med. ;61:319–325. doi: 10.7326/0003-4819-61-2-319
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Published: Ann Intern Med. 1964;61(2):319-325.
Hematology/Oncology, Red Cell Disorders.
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