JOHN E. BENNETT, M.D.
In the past few decades, countless microorganisms have been studied for their ability to produce useful antibiotics. It is a curious fact that the majority of clinically effective antibiotics, including amphotericin B (1), have been produced by actinomycetes (2). Among the few exceptions are the penicillins, griseofulvin, fumagillin and variotin, produced by fungi, and a group of antibiotics produced by bacteria: bacitracin, tyrothricin, polymyxin B, and colistin. There are over 400 antibiotic compounds and preparations derived from actinomycetes (3). Their combined spectrum of inhibitory action includes protozoa, (4), algae (5), tumor cells, fungi, spirochetes, bacteria, rickettsiae, pleuropneumonia-like organisms, and
BENNETT JE. Review of Selected Aspects of Pharmacology. Ann Intern Med. ;61:335–340. doi: 10.7326/0003-4819-61-2-335
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Published: Ann Intern Med. 1964;61(2):335-340.
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