JOHN P. UTZ, M.D.
The undesirable effects of the administration of the commercially available, colloidal (solubilized) form of amphotericin B may be divided into the idiosyncratic reactions, that is, those that occur in an isolated patient after usually only a small dose of drug, and the side effects that occur in almost every patient and are generally dose related. The idiosyncratic reactions include anaphylactoid shock, thrombocytopenia, acute liver failure, flushing, vertigo, generalized pain, grand mal convulsions, cardiac arrest, and ventricular fibrillation.
The side effects of intravenous administration include phlebitis, fever, chills, nausea, vomiting, headache, anorexia, hypokalemia, abnormal renal function, and anemia. The latter three
UTZ JP. General Side Effects. Ann Intern Med. ;61:340–343. doi: 10.7326/0003-4819-61-2-340
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Published: Ann Intern Med. 1964;61(2):340-343.
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