MICHAEL W. BRANDRISS, M.D.
Anemia has been noted frequently as a side effect of amphotericin B therapy in our patients. To determine the frequency, type, and possible mechanism of this anemia, we studied 30 patients with systemic fungal disease who received 37 courses of amphotericin B intravenously (1). The total dose of drug in any one course varied from 0.36 to 6.0 g. The mean hematocrit reading of the group prior to treatment was 41% and the mean low reading during therapy was 27%. A decrease in the hematocrit reading of more than 10 units occurred during 76% of the treatment courses and a
BRANDRISS MW. Anemia. Ann Intern Med. ;61:343–344. doi: 10.7326/0003-4819-61-2-343
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Published: Ann Intern Med. 1964;61(2):343-344.
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