GEORGE J. HILL II, M.D.
In early laboratory and clinical investigations of amphotericin B, the lethal dose range in animals and certain aspects of renal toxicity in animals and man were described (1, 2). Renal histologic changes were not recognized, however (3). In 1961 and 1962 isolated instances of nephrocalcinosis (4-7) were first reported, and soon thereafter a spectrum of renal histologic changes was attributed to amphotericin B therapy (8-11).
This is a summary of our experience to date with renal biopsy and necropsy studies in humans and dogs.
1. BIOPSY STUDIES
In ten amphotericin B treated and in three untreated patients
HILL GJ. Changes in Renal Morphology. Ann Intern Med. ;61:349–354. doi: 10.7326/0003-4819-61-2-349
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Published: Ann Intern Med. 1964;61(2):349-354.
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