KONG-OO GOH, M.D.; SCOTT N. SWISHER, M.D., F.A.C.P.
In 1960 Nowell And Hungerford demonstrated a "cancer cell marker" in cytogenetic studies of the leukocyte chromosome pattern in chronic myelocytic leukemia (1). This finding has been confirmed by others (2-6), and the name "Philadelphia" or "Ph1" has been applied to this abnormal chromosome (3).
Our interest in cytogenetic studies was stimulated by the difficulties encountered in the clinical differential diagnosis of occasional cases of chronic myelocytic leukemia (CML) and myeloid metaplasia (MM). It has been found that mature peripheral blood neutrophils in cases of polycythemia vera and in most cases of myeloid metaplasia have high activity of alkaline phosphatase.
GOH K, SWISHER SN. Specificity of the Philadelphia Chromosome: Cytogenic Studies in Cases of Chronic Myelocytic Leukemia and Myeloid Metaplasia. Ann Intern Med. ;61:609–624. doi: 10.7326/0003-4819-61-4-609
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Published: Ann Intern Med. 1964;61(4):609-624.
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