STEPHEN KRAUSS, M.D.; JOSEPH E. SOKAL, M.D.; AVERY A. SANDBERG, M.D.
Discovery of the Philadelphia chromosome (Ph1) in cases of chronic myelocytic leukemia (1) provided the first demonstration of a specific chromosomal abnormality in a human neoplasm. However, this abnormal cytogenetic feature is not present in all cases of this disorder, and a small number of patients said to be typical otherwise, but lacking the Ph1 chromosome, have been described (2). Since 1961, cytogenetic studies have formed part of the initial and subsequent hematologic investigation of patients with chronic myelocytic leukemia seen at this Institute. During this time, we have observed and treated both Ph1+ and Ph1- patients. The contrasts between
KRAUSS S, SOKAL JE, SANDBERG AA. Comparison of Philadelphia Chromosome-Positive and -Negative Patients with Chronic Myelocytic Leukemia. Ann Intern Med. ;61:625–635. doi: 10.7326/0003-4819-61-4-625
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Published: Ann Intern Med. 1964;61(4):625-635.
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