GERALD REAVEN, M.D.; LESTER SALANS, M.D.
Although treatment of diabetic patients with insulin has resulted in satisfactory control of hyperglycemia, its use has not significantly affected the incidence of diabetic retinopathy, neuropathy, nephropathy, or premature atherosclerosis. Indeed, the apparent increase in these manifestations of what might be referred to as the chronic diabetic syndrome would seem to raise the logical alternative that insulin is somehow involved in the genesis of these lesions. This possibility has been discarded in the past, primarily because all clinical manifestations of the chronic diabetic syndrome have been described in patients who never received insulin. This objection becomes less meaningful with recent
REAVEN G, SALANS L. Insulin-like Activity in Insulin-treated Patients with Diabetes Mellitus. Ann Intern Med. 1964;61:680–687. doi: 10.7326/0003-4819-61-4-680
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Published: Ann Intern Med. 1964;61(4):680-687.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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