Arthur C. Guyton, M.D.
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Many different research workers in the field of shock have recently come to the conclusion that one of the major factors that causes progression of shock is the deprivation of oxygen to the tissues resulting from diminished blood flow. This concept is supported by two primary types of evidence as follows: First, transport of oxygen to the tissues is even normally nearly "flow-limited." That is, a slight diminishment in cardiac output immediately begins to decrease the amount of oxygen used by the body. Thus, a 25% diminishment in cardiac output causes about 10% decrease in oxygen utilization; 50% decrease in
Guyton AC. Diminished Blood Flow and Oxygen Deprivation as Principal Factors in Progression of Shock.. Ann Intern Med. 1964;61:798. doi: https://doi.org/10.7326/0003-4819-61-4-798_1
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Published: Ann Intern Med. 1964;61(4):798.
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