T. B. Reynolds, M.D., F.A.C.P.; Hugh A. Edmondson, M.D., F.A.C.P.
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In 13 patients with chronic liver disease and positive LE cell tests, liver disease was usually insidious in onset and often far advanced when first discovered. Twelve of the patients were women, seven of whom were over 50 years of age. Characteristic laboratory findings were those of chronic liver disease, that is, albumin/globulin reversal, prothrombin depression, and marked transaminase elevation during episodes of jaundice.
During the earlier stages of the disease, liver biopsies showed active focal liver necrosis, diffuse intralobular round cell infiltration, and connective tissue and round cell increase in the portal triads. In the later stages a coarsely
Reynolds TB, Edmondson HA. Lupoid Hepatitis.. Ann Intern Med. 1964;61:804. doi: https://doi.org/10.7326/0003-4819-61-4-804_1
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Published: Ann Intern Med. 1964;61(4):804.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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