Warren D. Davidson, M.D.; Amory Sommaripa, M.D.; Patricia Wilkinson, M.D., M.R.C.P.
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Macroglobulinemia of Waldenstrom has been diagnosed with increasing frequency since it was first described in 1944. Two patients with this entity have recently been observed on the Medical Wards of the Philadelphia General Hospital. Both were middle-aged Negro males presenting with visual and auditory impairment. They were treated initially with plasmapheresis that reversed all symptomatology within a few days. Long-term therapy consisted of treatment with the alkylating agents chlorambucil and phenylalanine mustard. Complete symptomatic remission was obtained in one patient using the latter agent in large doses.
The macroglobulin of the latter patient was isolated and purified by repeated precipitation
Davidson WD, Sommaripa A, Wilkinson P. Macroglobulinemia.. Ann Intern Med. 1964;61:806–807. doi: https://doi.org/10.7326/0003-4819-61-4-806_4
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Published: Ann Intern Med. 1964;61(4):806-807.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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