Margaret J. Maclachlan, M.D.; Gerald P. Rodnan, M.D.; William M. Cooper, M.D., F.A.C.P.; Robert H. Fennell Jr., M.D.
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The nature of chronic active (so-called lupoid) hepatitis and its possible relationship to systemic lupus erythematosus (LE) is still obscure. We studied the clinical, pathological, and serological manifestations in fourteen women with chronic active hepatitis and marked hypergammaglobulinemia. Histologic examination of the liver in these patients has revealed a variable degree of liver cell necrosis and periportal inflammation characterized by infiltrations of lymphocytes and plasma cells and lesser number of eosinophiles and neutrophilic leukocytes. Some degree of scarring has been noted and it has become more marked as the disease has progressed.
A number of serologic abnormalities have been present
Maclachlan MJ, Rodnan GP, Cooper WM, Fennell RH. A Clinical and Serological Study of Chronic Active Hepatitis.. Ann Intern Med. ;61:808. doi: 10.7326/0003-4819-61-4-808_3
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Published: Ann Intern Med. 1964;61(4):808.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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