J. M. Martt, M.D., F.A.C.P.; C. Talbert Jr., M.D.; G. E. Lee, M.D.
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The drug 20, 25 diazacholestenol, a potent inhibitor of cholesterol biosynthesis, was administered to 42 subjects with hypercholesterolemia and coronary atherosclerosis in doses of 25 mg/100 ml/day for up to 20 months. Serum cholesterol was determined every 2 to 3 weeks and serum lactescence, liptoproteins, and phospholipids every 6 to 9 weeks. Photographs of the arcus senilis in the cornea and of xanthelasma and xanthomata were made every 3 months. Serum cholesterol fell in 41 of the subjects with a mean reduction of 78mg/100 ml (30%) from pretreatment levels. A less predictable but favorable response was also seen in the
Martt JM, Talbert C, Lee GE. Effect of 20, 25 Diazacholestenol on Serum Cholesterol.. Ann Intern Med. ;61:810. doi: 10.7326/0003-4819-61-4-810_3
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Published: Ann Intern Med. 1964;61(4):810.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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