Stanley Green, M.D., F.A.C.P.
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The widespread use of oral sulfonamide diuretics has stimulated an increasing awareness of their metabolic side effects, namely, hyperglycemia, and hypokalemia. The mechanism of hyperglycemia has not been satisfactorily explained.
Twenty-three well controlled diabetic patients were studied during a control period and for a prolonged period while on Chlorthalidone. The following data were collected: weight, blood pressure, blood sugar, serum potassium, uric acid, and urea nitrogen, 24-hr urinary 17-ketosteroids, 17-hydroxycorticosteroids, and aldosterone. During treatment approximately one half of the patients showed a significant rise in blood sugar and adrenal steroid excretion above control levels. The hyperglycemic response was inconsistent, occurring
Green S. The Effect of Oral Sulfonamide Diuretics on Carbohydrate Metabolism.. Ann Intern Med. ;61:812. doi: 10.7326/0003-4819-61-4-812_4
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Published: Ann Intern Med. 1964;61(4):812.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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