R. O. Mulhausen, M.D.; A. Eichenholz, M.D.
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With the exception of respiratory alkalosis, which has been extensively investigated, acid-base changes in patients with cirrhosis, with and without hepatic coma, have received little attention. This study reveals three patterns of acid-base disturbances. (1) Mixed metabolic-respiratory alkalosis was often associated with hypokalemia that occurred spontaneously or as a consequence of thiazide therapy. Potassium administration resulted in a correction of the plasma bicarbonate concentration. (2) Respiratory alkalosis was observed in various stages of compensation. Lactic and pyruvic acids accounted for most of the bicarbonate deficit necessary for partial or complete compensation of the alkalosis. (3) Metabolic acidosis of varying severity
Mulhausen RO, Eichenholz A. Acid-Base Abnormalities in Cirrhosis.. Ann Intern Med. ;61:814. doi: 10.7326/0003-4819-61-4-814_2
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Published: Ann Intern Med. 1964;61(4):814.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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