David Rifkind, Ph.D., M.D.; Thomas Startzl, M.D., Ph.D.; Thomas L. Marchioro, M.D.; William R. Waddell, M.D.
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Serious to fatal infections have occurred in 19 of the first 30 renal homotransplantations at The University of Colorado Medical Center and have constituted a primary factor in seven of the ten deaths that have occurred in this group. Immunologic attenuation of the recipient is accomplished by thymectomy and splenectomy, and more recently by splenectomy alone, plus azathioprine. In essentially all patients, homograft rejection tends to occur in the first post-transplant month, and this reaction must be suppressed by actinomycin C and by massive doses of corticosteroids.
The period of maximal risk from bacterial infections occurs at the time of
Rifkind D, Startzl T, Marchioro TL, et al. Infectious Diseases Associated with Renal Homotransplantation.. Ann Intern Med. 1964;61:815. doi: https://doi.org/10.7326/0003-4819-61-4-815_3
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Published: Ann Intern Med. 1964;61(4):815.
Infectious Disease, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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