Nathan W. Levin, M.B., F.C.P.(S.A.); James A. Hayashi, Ph.D.; Will G. Ryan, M.D.; Hermann Mattenheimer, M.D.; Robert M. Kark, F.R.C.P., F.A.C.P.
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Study of the isolated perfused kidney sacrifices normality in environment, but attains greater simplicity and a higher degree of experimental control. Although in recent years this preparation has been extensively used to study renal autoregulation, little attention has been paid to its potential usefulness in metabolic studies or in following the processes of renal failure. This presentation discusses the role of the isolated perfused kidney, describes experimental methods, presents serial data on fatty acid and glucose utilization during the course of failure of the kidney and on the enzymatic and histochemical changes that occur.
Levin NW, Hayashi JA, Ryan WG, et al. Perfusion of Isolated Animal Kidneys.. Ann Intern Med. 1964;61:816. doi: 10.7326/0003-4819-61-4-816_3
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Published: Ann Intern Med. 1964;61(4):816.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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