David P. Nicholson, M.D., M.R.C.P.
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There are a number of recorded instances of families who have shown inherited or familial nephritis. Familial hyperuricemic nephropathy has been described, and in line with current thought the renal disease was ascribed to the hyperuricemia. The following family demonstrates that the renal disease may be inherited as a dominant characteristic and that clinical and laboratory indications of gout may be secondary.
A 31-year-old married female, without issue, presented in June, 1961, with a history compatible with uremia and anemia. Over the next year the disease progressed to death in uremia with hyperchloraemic acidosis. Autopsy confirmed the presence of glomerulonephritis.
Nicholson DP. Inherited Nephropathy: A Family Instance Associated with Gout.. Ann Intern Med. 1964;61:816–817. doi: https://doi.org/10.7326/0003-4819-61-4-816_4
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© 2019
Published: Ann Intern Med. 1964;61(4):816-817.
DOI: 10.7326/0003-4819-61-4-816_4
Gout, Nephrology, Rheumatology.
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